TAK-33 inhibited and regressed tumor growth in melanoma cell lines and patient-derived xenograft models. This “robust” success in the lab, according to a study published in Nov. 5, 2014 in Molecular Cancer Therapeutics, justifies continued clinical development as a potential therapy for melanoma patients.
Advanced basal cell carcinoma (aBCC) is a term used to describe a subset of basal cell carcinomas (BCCs) that have extensive, invasive or metastatic involvement; are located near vital and sensitive areas; or are recurrent despite multiple treatments. The diagnosis of aBCC is dependent on many patient specific factors, some of which are subjective and may be open to interpretation by both the patient and provider.
Researchers have identified a functional biomarker that can predict whether BRAF-mutant melanomas respond to drugs targeting the gene. The finding could help guide treatment of patients with these cancers.