Xeroderma pigmentosum is a rare disease that leads to early skin cancer. New insights may lead to better prevention and survival for patients, as well as point to ways that UV-resistant gene functions could be used for skin cancer prevention and treatment.
Recent research supports UV radiation as the major driving force in the initiation and progression of melanoma, and the same investigation demonstrated different paths of evolution for various melanoma subtypes.
Diagnosing challenging melanocytic lesions typically requires combining immunostains—such as S100 and P16—with the dermatopathologist's subjective judgment, says an expert. Adjunctive genetic tests and morphologic analysis can provide further clues, though neither method is infallible.
Optometrists in a practice unaffiliated with a tertiary care center will rarely see patients ocular cancer, a disease that is both sight threatening and life threatening. Because it’s impossible to predict who will walk through your door, it’s necessary to remain vigilant for signs of ocular melanoma, basal cell carcinoma, ocular lymphoma and leukemia, as well as cancers that have metastasized to the eye.