melanoma

Managing conjunctival pigmented lesionsKnowing how to recognize and manage the various forms of conjunctival pigmented lesions can literally mean the difference between life and death in some cases.
From mole to melanomaThere is a genetically intermediate state of melanocytic neoplasia and these findings could someday help doctors identify high-risk lesions to remove before they become malignant.
Molecular age of melanomaThe field of molecular diagnostics, as it pertains to dermatology, has truly exploded in the last decade, according to one expert.
Skin cancer screeningData-driven screening guidelines for skin cancer have been published electronically, in reaction to the U.S. Preventive Services Task Force’s 2016 draft recommendation statement on skin cancer screening.
Lasers in melanoma careLaser for melanoma in situ (MIS) should generally be reserved for nonsurgical, usually elderly patients. When indicated, MIS may be treated with CO2 laser or with combined Q-switched Nd:YAG and imiquimod. Any atypical-appearing lesion should be biopsied prior to the start of a laser treatment.
Sunlight and its effect on eye healthAvoiding sunlight entirely appears to be a misdirection. Melanoma is inversely related to latitude and inadequate acclimation (i.e., increased melanization and epidermal thickening), which carries the risk of both melanoma and non-melanoma skin cancer—common in northern latitudes.
Skin cancer advancesGenetic profiling is valuable in both diagnosis and prognosis of skin cancer. Hedgehog inhibitors and (superficial radiation therapy) SRT are strong contenders for treating nonmelanoma skin cancer. Advances in targeted therapies and biologics are part of the new wave of melanoma treatments.
Melanoma surgical management guidelinesAll surgical management of melanoma is defined by Breslow thickness. For melanoma less than 1 mm in thickness, typically a SLNB is not required. Future imaging devices may better delineate the extent and depth of the tumor in vivo.
Psoriasis and skin cancerCyclosporine and PUVA clearly increase the risk of squamous cell carcinomas, and there is evidence that TNF blockers and methotrexate may do so to a lesser degree. UVB phototherapy has not been shown to cause skin cancer. Acitretin offers protection against the development of basal cell and squamous cell carcinomas.
Genetic testing for melanoma riskPatients who carry a high-penetrance melanoma predisposition gene can often benefit from screening for other cancers. Patients who receive a positive genetic test result are more likely to embrace prevention and detection measures. A new “Rules of Three” proposes a point-based guideline to help determine who should be referred for genetic counseling and testing.