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Hot Topics in Prostate Cancer

Greater long-term side effect risk with intermittent ADTIn men with metastatic prostate cancer, those assigned to intermittent androgen deprivation therapy have more ischemic and thrombotic events than those assigned to continuous androgen deprivation, according to Columbia University researchers.
No link between PDE-5 use, prostate Ca recurrenceNo significant relationship was found between use of a phosphodiesterase type-5 inhibitor and prostate cancer recurrence after treatment in a nested case-control study.
Salvage HIFU shows promise in post-RT PCa patientsHigh-intensity focused ultrasound as salvage therapy allows for intermediate-term disease control in selected patients with recurrence following radiation therapy for prostate cancer.
Modalities for high-risk PCa yield similar outcomesTreatment options for high-risk prostate cancer perform similarly. In a single-institution study, radical prostatectomy was associated with worse biochemical failure, less clinical failure, and superior prostate cancer-specific mortality compared with radiation therapy and brachytherapy, reported Jay P. Ciezki, MD, at the 2016 Genitourinary Cancers Symposium in San Francisco.
How RT dose escalation affects prostate Ca outcomesA meta-analysis of 6,884 men with prostate cancer who underwent external beam radiation therapy reveals surprising findings about dose escalation.
Experimental prostate Ca urinary test outperforms PSAThe three-gene expression assay could “reduce hundreds of thousands of invasive biopsies each year,” a study author says.