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Hot Topics in Prostate Cancer

Prostate Ca: PSA drop, active surveillance are key themesFusion biopsy, salvage versus adjuvant radiation therapy, and superextended versus extended pelvic lymph node dissection are also covered in the take home messages on prostate cancer from the 2016 AUA annual meeting.
Landmark prostate cancer screening trial criticizedThe authors of a recent NEJM letter question the validity of the controversial Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.
Active surveillance initiative raises adoption of strategyAn academic center/community practice collaboration increases use of surveillance among prostate cancer patients “through use of provider education and a standardized report card,” a study author said.
Assay predicts outcomes in men taking mCRPC agentExpression of androgen receptor splice variant 7 (AR-V7) in whole blood predicts worse cancer-related outcomes in patients with metastatic castration-resistant prostate cancer who are treated with abiraterone acetate (ZYTIGA).
Prostate HIFU lands in the U.S. Now what?"With all this uncertainty, the good news is that men will no longer need to travel to Canada or elsewhere for prostate HIFU therapy," writes Leonard G. Gomella, MD.
Prostate biopsy-related infections raise transfusion riskParadoxically, the authors of a large study did not find a negative effect in functional outcomes analyzed.
Use of observation for PCa varies widely among urologistsA CMS quality measure needs to be bidirectional, “specifying a rate of observation for low-risk disease and a rate of treatment for high-risk disease,” researchers say.
Peri-op transfusion raises short-term morbidity riskA retrospective analysis looks at the short-term morbidity associated with transfusion among patients in the National Surgical Quality Improvement database.
Study finds prostate Ca clones trackable by fusion biopsySpecific clones may have the potential for grade conversion, research suggests.
AS success rate strong in appropriate PCa patientsLarge study examines surveillance results in men with very low-, low-, intermediate-, and high-risk disease.