fluoroquinolones

Reviewing anterior segment ARVO 2017 postersSo much basic science research is presented at this meeting, and most of it will be years before it makes its way to clinical trials. Let’s concentrate on research that might be of use to us in the exam room very soon.
How to evaluate the guidelines of antibiotic reactions in surgeryEye surgeons should use intracameral antibiotics only in select situations; they should avoid aminoglycosides, and they should not use vancomycin as prophylaxis. Michael Jumper, MD, offered this perspective as part of an overview of antibiotics used in intraocular surgery during the Glaucoma Symposium at the 2017 Glaucoma 360 meeting.
FDA: Antibiotics class must carry warningFDA added new safety labeling changes for a class of antibiotics, fluoroquinolones (Levaquin, Cipro and other branded drugs), to enhance warnings about their association with disabling and potentially permanent side effects. Plus, the new labeling says that the drugs’ use should be limited in patients with less serious bacterial infections.
Pre-op antibiotics sufficient to prevent UTI during stone TxBrian Howard Eisner, MD, examined antibiotic use in ureteroscopy and PCNL in two studies presented at the AUA annual meeting in New Orleans. He discusses the studies’ findings with Urology Times.
Moxifloxacin, ciprofloxacin connected to uveitis riskA recent study published in JAMA Ophthalmology found that current use of moxifloxacin (Avelox, Bayer) or ciprofloxacin (Cipro, Bayer) appears to increase the risk for uveitis.
Most fluoroquinolones use not connected with glaucoma riskA recent study published in the Journal of Glaucoma found that there was no detected increase in glaucoma risk with current, recent, or past use of systemic fluoroquinolones, but did find a minimal statistically significant increased risk with distant use.
Shortage of IV metronidazole antibiotic prompts indication-specific alternativesThere has been a recent national backorder of iv Metronidazole (Flagyl) due to manufacturing delays with Hospira. As a result of this delay Hospira has not been able to provide a tentative timeline or estimate date of when IV metronidazole will be available to purchasers/buyers once again. While this situation plays out, there are general management strategies that might be implemented based on the facility.
MRSA strain persists in homes after infectionSince the late 1990s, USA300, a strain of methicillin-resistant Staphylococcus aureus (MRSA), has spread across the United States, contributing to an epidemic of community-associated MRSA. The strains can persist in residential homes after infections, according to a study published in the Proceedings for the National Academy of Sciences.
Community-associated MRSA epidemic linked to fluoroquinolone usageSince the late 1990s, USA300, a strain of methicillin-resistant Staphylococcus aureus (MRSA), has spread across the United States, contributing to an epidemic of community-associated [CA] MRSA. The strains can persist in residential homes after infections, and appear to be linked to high usage of fluoroquinolones, according to a study published in the Proceedings for the National Academy of Sciences.
FDA neuropathy warning on fluoroquinolonesFDA calls for Drug labels and Medication Guides for all fluoroquinolone antibacterial drugs to be updated with better descriptions of the serious side effect of peripheral neuropathy in arms or legs.