Contemporary Pediatrics Journal Club

Known HRV infection may not decrease risk of IBIInfection with human rhinovirus (HRV) confirmed by polymerase chain reaction (PCR) does not decrease the likelihood of concurrent urinary tract infection (UTI) in infants aged from 1 to 90 days old, according to a study in well-appearing febrile infants in this age group.
BRUE in infancy does not increase risk of deathA meta-analysis of 12 studies of the risk of death after a brief resolved unexplained event (BRUE) found that such an event does not increase an infant’s risk of dying during his or her first year. The American Academy of Pediatrics (AAP) introduced BRUE, a sudden alteration in an infant’s breathing, color, tone, or responsiveness, as a replacement for “apparent life-threatening event” (ALTE) in a 2016 clinical practice guideline.
Urinalysis identifies the youngest infants with UTIsUrinalysis is extremely sensitive and specific for screening for urinary tract infections (UTIs) in febrile infants aged 60 days and younger, especially when the UTI is associated with bacteremia, a recent study showed.
Pediatricians rarely discuss umbilical cord blood banking with parentsOnly 22% of pediatricians speak to prospective parents about umbilical cord blood banking (UCBB), according to a survey of 473 general and subspecialty pediatric providers.
Can salivary microRNA levels identify risk for prolonged concussion symptoms?A study in children with mild traumatic brain injury found that concentrations of 5 salivary microRNAs (miRNAs) identified prolonged concussion symptoms with 85% accuracy, suggesting that the answer to this question is “yes.”
Rhinovirus and osteoarticular infections due to K kingae have the same seasonalityHuman rhinovirus (HRV) and Kingella kingae osteoarticular infections are highly active at the same time of year—the fall—a study in Paris found.
Top 10 studies you can't missDr. Michael Burke has selected 10 articles published during the last 12 months in Contemporary Pediatrics that he says are worth a second look.
New hemophilia B gene therapy appears effectiveA recent trial showed that a single intravenous infusion of a vector expressing a high specific-activity factor IX gene safely produces a sustained, effective level of factor IX coagulant activity in patients with hemophilia B.
Novel biomarker accurately identifies infants with UTIsUrinary neutrophil gelatinase-associated lipocalin (uNGAL) is highly sensitive and specific for diagnosing urinary tract infections (UTIs), according to a study in febrile children aged up to 24 months.
High-nicotine e-cigarettes lead to more smoking and vapingCompared with adolescents who use e-cigarettes with relatively low or no nicotine concentrations, those who use e-cigarettes with higher nicotine concentrations are more likely to progress to more frequent and intense combustible cigarette smoking and vaping.