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Making good decisions requires that physicians have reliable and practical data. Comparative effectiveness reviews and objective findings on different medical interventions and strategies, as provided by the Agency for Healthcare Research and Quality in its Effective Health Care Program, can help physicians make the most informed choices among treatment options.

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Effective Health Care Clinician Guides

Dominant optic atrophy a common neuropathy

The analysis of clinical and molecular genetic data has provided new informatioand natural history of autosomal-dominant optic atrophy due to OPA1 mutations.

Methylene blue linked to serious CNS reactions

FDA has received reports of serious central nervous system reactions when methylene blue is given to patients taking serotonergic psychiatric medications.

FDA Safety Alert: REMS required with belatacept

Patients treated with belatacept (Nulojix, Bristol-Myers-Squibb) are at increased risk of developing 2 potentially fatal complications: post-transplant lymphoproliferative disorder (PTLD), which predominantly involves the central nervous system, and progressive multifocal leukoencephalopathy, according to a recent FDA Safety Alert. The risk of PTLD is higher for transplant patients who have never been exposed to Epstein-Barr virus (EBV) and therefore is indicated for use only in transplant patients who are EBV seropositive.

Criteria updated in diagnosis of Alzheimer's disease

According to new guidelines, researchers at the Alzheimer's Association and the National Institute of Aging of the National Institutes of Health have categorized AD into 3 different stages: preclinical, mild cognitive impairment, and Alzheimer's dementia.