Weight Gain Increases Severity of Polycystic Ovary Syndrome Publish date: Nov 5, 2008 ![]() WEDNESDAY, Nov. 5 (HealthDay News) -- Excess postnatal weight gain exacerbates disruptions in reproductive phenotype caused
by excess prenatal testosterone exposure, and can increase the severity of polycystic ovary syndrome, according to research
published online Oct. 30 in Endocrinology. Teresa L. Steckler, of the University of Michigan in Ann Arbor, and colleagues examined the effect of postnatal weight
gain on an animal model of polycystic ovary syndrome, in which sheep were prenatally treated with testosterone. After weaning,
female sheep were divided into groups and either fed normally or overfed to achieve a 25 percent increase in body weight.
Blood samples were taken to determine the effect of excess weight gain on menstrual cycle and periovulatory dynamics. A definable luteinizing hormone surge was observable in 100 percent of non-treated controls, but only 43 percent of the
prenatal testosterone-treated sheep, the researchers report. This dropped to 14 percent in overfed prenatal testosterone-treated
sheep. Similarly, 100 percent of control sheep, 87.5 percent of prenatal testosterone-treated sheep and 14 percent of overfed
prenatal testosterone-treated sheep showed an elevation in luteal progesterone. This study found that excess weight gain increases the reproductive defects previously shown in prenatal testosterone-treated
sheep. According to the authors, the findings "agree with the increased prevalence of anovulation observed in obese women
with polycystic ovary syndrome." Copyright © 2008 ScoutNews, LLC. All rights reserved. | Coding Counselor Simple and accurate ICD-9 code search. Start Here Formulary Counselor Find health plan drug coverage in your area. Start Here Patient Education Print customized patient education handouts. Start Here Surgical Video Center On-demand surgery demos and presentations. Start Here ![]() ![]()
|