TUESDAY, Dec. 22 (HealthDay News) -- In women with atypical squamous cells of unknown significance and a negative human papillomavirus (HCII) test, nearly all achieve cytologic regression within two years, according to a study in the December issue of the American Journal of Obstetrics & Gynecology.

Shu Wang, M.D., of the Peking Union Medical College Hospital in Beijing, and colleagues followed 45 women with baseline atypical squamous cells of unknown significance and negative high-risk human papillomavirus for two years.

The researchers found that rates of cytologic regression at six months, one year, and two years were 55.6, 84.4, and 95.6 percent, respectively, and that age, menopausal status, and baseline HCII load had no effect on regression. They also found that the one-year regression rate was lower in women with previous cervical lesions and even lower in those with high-grade intraepithelial neoplasia.

"Consequently, almost all women with atypical squamous cells of unknown significance and negative HCII results could obtain cytologic regression without any treatment," the authors conclude.

Abstract
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