Pulmonary arterial hypertension is a serious and often progressive disorder that may be idiopathic or associated with various underlying medical conditions. PAH causes right ventricular dysfunction and impaired activity tolerance, and can lead to right-heart failure and death. The diagnosis and assessment of PAH has been rapidly evolving, with changes occurring in the definition of the disease, screening and diagnostic techniques, and staging and follow-up assessment. After completing this activity, the participant will demonstrate the ability to explain the pathophysiology of PAH; determine when and how to screen patients for PAH; describe current therapies in the management of PAH; appropriately monitor patients receiving treatment for PAH.