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Injectable Polymer Corrects Wrinkles Better Than Collagen

Poly-L-lactic acid injections found to be effective in treating nasolabial fold wrinkles


FRIDAY, March 19 (HealthDay News) -- Injectable poly-L-lactic acid (PLLA), a synthetic, biodegradable, biocompatible polymer device, is more effective in correcting nasolabial fold wrinkles than collagen, with effects observed as long as 25 months after the last treatment, according to a study in the March issue of the Journal of the American Academy of Dermatology.

Rhoda S. Narins, M.D., from the New York University School of Medicine in New York City, and colleagues randomly assigned 233 healthy patients (mostly Caucasian women) with nasolabial fold wrinkles to injection with human collagen or PLLA.

The researchers found that patients treated with PLLA had significant wrinkle correction as assessed by the Wrinkle Assessment Scale. The improvements with PLLA were significantly better than with collagen from three to 13 months after the last treatment, and the benefits of PLLA were still observed 25 months after the last treatment.

"The results of this study demonstrate that injectable PLLA is safe and effective for the cosmetic correction of nasolabial fold wrinkles in an immunocompetent population, and that the improvement is gradual and long-lasting, maintained for up to 25 months after last treatment," Narins and colleagues conclude. "The efficacy of injectable PLLA will provide subjects and physicians with a new treatment option for the correction of nasolabial fold wrinkles."

The study was sponsored by Dermik Laboratories. Several authors reported advisory, consulting, and financial relationships with Dermik Laboratories and BioForm Medical Inc.

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