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    AAD: Hyaluronic Acid Increases Fibroblast Activity

    And, nanotechnology shows promise for use in treatments for melanoma, other skin conditions

    FRIDAY, March 5 (HealthDay News) -- Recent research suggests how the popular skin filler hyaluronic acid works to rejuvenate photoaged skin, and nanotechnology may have potential for use in cosmetic products and topical medical treatments, according to two presentations this week at the annual meeting of the American Academy of Dermatology, held from March 5 to 9 in Miami Beach, Fla.

    In one presentation, Dana L. Sachs, M.D., of the University of Michigan in Ann Arbor, presented results of an initial study of six patients showing that hyaluronic acid injections stimulate production of type I collagen, and a subsequent study of 11 patients showing that the mechanism behind this process is increased activity of fibroblasts, which were observed at four and 13 weeks following injection to be in a 'stretched' configuration that correlates with increased collagen production.

    In a second presentation, Adnan Nasir, M.D., of the University of North Carolina in Chapel Hill, discussed the pros and cons of nanotechnology and how nanoparticles may someday be used to enhance the effectiveness of cosmetic products such as sunscreens, shampoos and conditioners; anti-aging products such as retinoids, antioxidants, botulinum toxin, and growth factors; and treatments for conditions such as melanoma, atopic dermatitis, and ichthyosis. However, he cautioned that the future of nanotechnology in dermatology depends on the results of an ongoing safety review by the U.S. Food and Drug Administration.

    "Research in the area of nanotechnology has increased significantly over the years, and I think there will be considerable growth in this area in the near future," Nasir said in a statement. "The challenge is that a standard has not been set yet to evaluate the safety and efficacy of topical products that contain nanosized particles."

    Press Release - Sachs
    Press Release - Nasir
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